2024年4月28日发(作者:洪陶然)
肠道病毒
1Jan.2006nfectionsl5
Enteroviruses
PeterMuIr
Th??enten,vjnIsP~ll-f-,ElIarg~-gPI1Usorv1YLIswit}1iI1Il1PT1i—
r131navinISI¨I1jlv—RNAvirllseslI1IitI"in{ILIflP【brtli—
nt?vITLIsesa『lcI}1f】patiIisAll_..|1IerfliI'LlPIPspread~i目
I}14raPI_t)raIr<+tlleanIjInitJatiI1fectI_,iliIit}1gaMrel】11r1i-
halIra(.【.tholIghII1yart~IloLaigIljIicttlll('ItIIS4~"Ilfgasln?rll—
fPrIIlA1]}LIt64?tisliI1(-【sr(11YnsaIkfiewIItoiIlfiIiLL—
lIltlll~AandBC(~xsackie
,i【-1Iss1CVA.【:V17.}andc,t-Il1)ViI31sP
Classifieation
ChlssifiItioliIlI'rlo[i—I川li【l『_Lerf]viruPkl~Ci)xsackjviitlHrs
I)T(j.-hnvinisesWitSoriginallyhaPdI)11I.'jIpath~)gf!lli(-ilyin
rl¨I【Jl1ts;CVAaillICVBcHIJ?uJflatf-i1tcirI1aIlI-paralvsisre.
Sl1PlIivPlvin,l【'a~irlvirtlSeSwerei1l111.
palli,<~,,.dlJgicalclas,4fi(-alienisnc】Ionizer
l『1sjrlere~】use|『1a11(?wtaxonomy}msedllnIilte4-L1】ar
genl【i(tsIl1l1l~lPltWsisi]ingaiHiiiig【1itilllc,
Fhis111111~t?tlI}-rtIxIInrlJl1iirllF,oilanlhiFLIl1derstan(Ing
'-|1terovinisI_li?,IIJgyilllfilrIhPsttIvrtJ1IjII1t)】Ptdarepi—
dellliul(Y)I'enle~lvlluinf(n-tili[INnNktlll[,le,mole(iliar
PI1Pn1'I1.)gyIiⅢ,ic1.-l1iiq~aILlaJ)It-lI1)rmali'?nOlithe
progresscftlIWHO【HiiJ1a(1i~aI_I¨tiff'一
ingreservoirssustainingtransmi~,sionofpollovirusall[1tile
III1.I】?telIviFLINe,%ihiedrawhPl'PPrar"catil)I1has
purrH'-I】fI-】iniffl】ll1anagTl_PIlI.
howe~.'ldom『lcPss}【Ivl【1differf'llIialP【)eiweefl{】jf—
l】PillPnler'(iI"UHtypes
I'woYiI"1Jel11lvilIuHlvkiiclw『la,P?-hIvirllIv[It~S22HIl'l23
ar『l【lWkn【1wDI4?Igeneti~}llIvI=JisliI1(-t-m【l1eothreJ】_
【?l1,virusPan【lhavPhPIIre{-Iassifiediii_I_1t-wgl~1]lJSa_lLI.
manpare~.hrwinislyI】lRelyThcsigrtifiuante
0f'ihisliolrTIdyacacietni.1]it(trillS,f"Illodelqldiagnostit-
melIiJIkSllChaspolytneraseL-hainrParIionfPCRIallab.~pis
andantigenrielet~tionft?【llr)w1.w】1iIlIiarI?dPsignedtode—
teeta}irolt(J¨iiigeoflilel'prolypPs.【l(1notdete(-Ithe
pan?rhovilLJP^
Diagnosisofenterovirusinfections
A¨houghIherei,4'II1rentlyni】~pecifi(:antiviraltherapy1j-
Cp/l:~Pdf)rc~1iolngh.j_L】diagnosis
ma)tleVet'IhelesslievaILJdIindifferentiating~,ntertwii'LIS
PeterMuir,saCIi:t]l,o~lSc~eot,'stattheHeaflhPro~ectionAgencySos,t,G
WeslRoQiO,',,,0ned
Cfed
MEDICINEINTERNAT10NAL
howedpro?
miseinpre—clinicaltrials,hasbeenwithdrawnbecause
ofside-effects
Only1252casesofpoliomyelitiswerenotifiedin2004,all
,PakistanofNiger
Largeepidemicsofenterovirustype71一associatedha—
dmouthdiseasehaveoccurrecIincountries
aroundthePacificbasin
lnl'l,orionfr,)ble('rf'-enll','.di.
2024年4月28日发(作者:洪陶然)
肠道病毒
1Jan.2006nfectionsl5
Enteroviruses
PeterMuIr
Th??enten,vjnIsP~ll-f-,ElIarg~-gPI1Usorv1YLIswit}1iI1Il1PT1i—
r131navinISI¨I1jlv—RNAvirllseslI1IitI"in{ILIflP【brtli—
nt?vITLIsesa『lcI}1f】patiIisAll_..|1IerfliI'LlPIPspread~i目
I}14raPI_t)raIr<+tlleanIjInitJatiI1fectI_,iliIit}1gaMrel】11r1i-
halIra(.【.tholIghII1yart~IloLaigIljIicttlll('ItIIS4~"Ilfgasln?rll—
fPrIIlA1]}LIt64?tisliI1(-【sr(11YnsaIkfiewIItoiIlfiIiLL—
lIltlll~AandBC(~xsackie
,i【-1Iss1CVA.【:V17.}andc,t-Il1)ViI31sP
Classifieation
ChlssifiItioliIlI'rlo[i—I川li【l『_Lerf]viruPkl~Ci)xsackjviitlHrs
I)T(j.-hnvinisesWitSoriginallyhaPdI)11I.'jIpath~)gf!lli(-ilyin
rl¨I【Jl1ts;CVAaillICVBcHIJ?uJflatf-i1tcirI1aIlI-paralvsisre.
Sl1PlIivPlvin,l【'a~irlvirtlSeSwerei1l111.
palli,<~,,.dlJgicalclas,4fi(-alienisnc】Ionizer
l『1sjrlere~】use|『1a11(?wtaxonomy}msedllnIilte4-L1】ar
genl【i(tsIl1l1l~lPltWsisi]ingaiHiiiig【1itilllc,
Fhis111111~t?tlI}-rtIxIInrlJl1iirllF,oilanlhiFLIl1derstan(Ing
'-|1terovinisI_li?,IIJgyilllfilrIhPsttIvrtJ1IjII1t)】Ptdarepi—
dellliul(Y)I'enle~lvlluinf(n-tili[INnNktlll[,le,mole(iliar
PI1Pn1'I1.)gyIiⅢ,ic1.-l1iiq~aILlaJ)It-lI1)rmali'?nOlithe
progresscftlIWHO【HiiJ1a(1i~aI_I¨tiff'一
ingreservoirssustainingtransmi~,sionofpollovirusall[1tile
III1.I】?telIviFLINe,%ihiedrawhPl'PPrar"catil)I1has
purrH'-I】fI-】iniffl】ll1anagTl_PIlI.
howe~.'ldom『lcPss}【Ivl【1differf'llIialP【)eiweefl{】jf—
l】PillPnler'(iI"UHtypes
I'woYiI"1Jel11lvilIuHlvkiiclw『la,P?-hIvirllIv[It~S22HIl'l23
ar『l【lWkn【1wDI4?Igeneti~}llIvI=JisliI1(-t-m【l1eothreJ】_
【?l1,virusPan【lhavPhPIIre{-Iassifiediii_I_1t-wgl~1]lJSa_lLI.
manpare~.hrwinislyI】lRelyThcsigrtifiuante
0f'ihisliolrTIdyacacietni.1]it(trillS,f"Illodelqldiagnostit-
melIiJIkSllChaspolytneraseL-hainrParIionfPCRIallab.~pis
andantigenrielet~tionft?【llr)w1.w】1iIlIiarI?dPsignedtode—
teeta}irolt(J¨iiigeoflilel'prolypPs.【l(1notdete(-Ithe
pan?rhovilLJP^
Diagnosisofenterovirusinfections
A¨houghIherei,4'II1rentlyni】~pecifi(:antiviraltherapy1j-
Cp/l:~Pdf)rc~1iolngh.j_L】diagnosis
ma)tleVet'IhelesslievaILJdIindifferentiating~,ntertwii'LIS
PeterMuir,saCIi:t]l,o~lSc~eot,'stattheHeaflhPro~ectionAgencySos,t,G
WeslRoQiO,',,,0ned
Cfed
MEDICINEINTERNAT10NAL
howedpro?
miseinpre—clinicaltrials,hasbeenwithdrawnbecause
ofside-effects
Only1252casesofpoliomyelitiswerenotifiedin2004,all
,PakistanofNiger
Largeepidemicsofenterovirustype71一associatedha—
dmouthdiseasehaveoccurrecIincountries
aroundthePacificbasin
lnl'l,orionfr,)ble('rf'-enll','.di.